Yucca Health GLP-1 Reviews: Is It Legit, What Does It Really Cost, and Should You Sign Up?
You searched "Yucca Health GLP-1 reviews" because you saw the price, it caught your attention, and now you need to know: Is this real? What's the catch? Am I going to regret this?
We spent the time so you don't have to. We reviewed Yucca's pricing pages, FAQ, Terms of Service, refund and shipping policies, safety disclosures, their current Trustpilot profile (900+ reviews), Reddit threads, and public pricing from the major alternatives.
Here's the short answer.

The Verdict (Read This First)
Yucca Health is a legitimate telehealth platform.
It connects you with licensed U.S. providers and licensed U.S. pharmacies for compounded GLP-1 medications — semaglutide and tirzepatide. Trustpilot currently shows about 909 reviews with a 4.6 rating (“Excellent”), starter pricing as low as $146/month for semaglutide, and a personal onboarding process that patients consistently rave about.
The main tradeoff to understand upfront
Yucca's GLP-1 medications are compounded — not FDA-approved finished drugs. If your insurance covers brand-name Wegovy or Zepbound, or you specifically want FDA-approved medication, Yucca is not your best route. But if you're paying out of pocket comparing compounded telehealth options, that's exactly why Yucca's pricing can start so much lower.
Best for
Cash-pay patients comfortable with compounded GLP-1 medications who want some of the lowest published pricing, personal onboarding with a real human, and a structured support system — without hidden membership fees.
Not best for
Anyone who wants FDA-approved brand-name medication, needs insurance billing, or requires itemized HSA/FSA receipts. If that's you, compare brand-name GLP-1 routes.
| At a Glance | Details |
|---|---|
| Semaglutide starter price | From $146/mo (new patients, 6-month plan) |
| Tirzepatide starter price | From $258/mo (new patients, 6-month plan) |
| Membership / enrollment fee | None |
| Provider review | Licensed U.S. physician, typically within 24 hours |
| Shipping | UPS 2-Day Air, Mon–Fri, temperature-controlled |
| Insurance | Not accepted. HSA/FSA can be used (no itemized receipts) |
| Refund policy | No refunds once medication ships. Refunds for billing errors, duplicate charges, or non-approval only |
| Trustpilot | 4.6/5, ~909 reviews, rated "Excellent" |
| Charged before approval? | No. Temporary hold only — charged only if provider approves |
Pricing from tryyucca.com as of March 2026. Confirm exact charges during checkout.
If that matches what you're looking for, you can check current pricing and eligibility directly — you'll only be charged if a licensed provider approves your treatment.
4.6/5 Trustpilot · 909+ Reviews · No Charge Until Approved
Check your eligibility on Yucca Health
Free online health assessment. You're only charged if a licensed provider approves your treatment. Starter pricing from $146/mo.
Check Your Eligibility on Yucca Health →Quick Navigation
Who Yucca Health Is Best For — And Who Should Skip It
Before we go deeper, let's make sure you're in the right place.

Yucca is a strong fit if you are:
- Paying out of pocket for GLP-1 medication (no insurance coverage, or your copay exceeds $150–260/month anyway)
- Comfortable with compounded medication — you understand it's not brand-name Ozempic or Wegovy, and that's fine with you because the price matters more
- New to GLP-1s and want hand-holding — Yucca's onboarding includes a phone call from a real person who walks you through everything. This shows up in Trustpilot review after review — patients mention team members by name (Hazel, Johann, Rachelle, Sam) — and it's not something most telehealth competitors offer
- Looking for the lowest upfront semaglutide price in the compounded telehealth space
- In the United States — Yucca ships domestically only
Skip Yucca and look elsewhere if you:
- Want or need brand-name FDA-approved medication (Wegovy, Zepbound, Ozempic, Mounjaro) — compare brand-name routes
- Need your provider to bill your insurance — Yucca does not accept insurance at all
- Need itemized receipts or letters of medical necessity for HSA/FSA reimbursement — Yucca explicitly says they do not provide these
- Want generous refund flexibility — once your medication ships, it's final sale
- Prefer oral medication over injections — Yucca currently offers injectables only
Does the first list sound like you? Most people reading Yucca Health GLP-1 reviews fall into that group. You're paying cash, you want affordable access to compounded GLP-1 treatment, and you just need to know it's safe, real, and worth the money.
No charge until a licensed provider approves your treatment
What Is Yucca Health, Exactly?
A quick clarification first: if you've seen “yucca” results on WebMD about a plant supplement — that's not this. Yucca Health (tryyucca.com) is a telehealth brand. Completely different thing. WebMD does not currently have a review of Yucca Health the telehealth platform.
Yucca Health is a telehealth platform — not a pharmacy and not a medical practice. It connects three things together for you:
- The platform (Yucca) manages the technology, your patient portal, billing, onboarding, and coordination.
- Licensed physicians evaluate your medical history and make prescribing decisions. Yucca publicly lists Dr. Michael Wasef, MD, a board-certified Internal Medicine physician “licensed nationwide,” along with Dr. Frank Suppa, DO, and Dr. Andrew Sakla, DO, on its clinical team.
- Licensed U.S. compounding pharmacies prepare and ship your medication.
This three-part structure is standard for telehealth platforms in this space. Medical decisions are made by the providers, not by Yucca's business team. That separation matters.
Yucca offers two compounded GLP-1 medications:
- Compounded semaglutide — a GLP-1 receptor agonist prescribed for weight management. This is a compounded medication prepared by licensed U.S. pharmacies — it is not FDA-approved as a finished product and is not the same as brand-name Ozempic or Wegovy.
- Compounded tirzepatide — a dual GLP-1/GIP receptor agonist prescribed for weight management. This is a compounded medication prepared by licensed U.S. pharmacies — it is not FDA-approved as a finished product and is not the same as brand-name Mounjaro or Zepbound.
Both are compounded by licensed U.S. pharmacies and prescribed by licensed U.S. providers when determined medically appropriate.
How Yucca Health Works: The Step-by-Step Process
One of the biggest anxieties people have is simply: what actually happens after I hit “submit”?
Here's exactly what to expect.

Complete the intake form online (5–10 minutes)
Answer questions about your health history, weight, current medications, and goals. This is a real medical evaluation — your answers directly influence whether a provider approves you and which medication and dose they recommend.
Choose your plan and authorize payment
Pick semaglutide or tirzepatide, select your plan length (monthly, 3-month, or 6-month), and enter your payment info. A temporary hold appears on your card — but you are NOT charged unless a provider approves your treatment.
Verify your identity
Typically uploading a government-issued ID or completing verification through a third-party service. Standard legal requirement for telehealth prescribing — your data is handled under HIPAA-compliant encryption.
Licensed provider reviews your intake (typically within 24 hours)
Asynchronous review — no live video call required. The provider may message you through the secure patient portal if they have questions.
Medication is compounded and shipped
If approved, a licensed U.S. pharmacy compounds your medication and ships via UPS 2-Day Air (Mon–Fri only for cold-chain integrity). Most patients receive medication within about one week.
You get a personal onboarding call
A real person from Yucca's care team calls you to walk through your portal, medication, dosing schedule, and any questions. Patients name these team members in reviews — Hazel, Johann, Rachelle, Sam, Honey — and consistently rate this experience highly.
Ongoing care and dose adjustments
Your provider manages your dose titration over time. You have ongoing access to the patient portal for messaging, support, and tracking.
Realistic Timeline
| Day 1 | Submit intake |
| Day 1–2 | Provider review |
| Day 3–5 | Pharmacy compounds medication |
| Day 5–7 | UPS 2-Day Air delivery |
| Day 7–8 | Onboarding call |
Most patients have medication in hand within about a week.
What Comes in the Box
When your shipment arrives, it's packed on ice in temperature-controlled packaging. Yucca's pricing pages note a “Home Injection Kit” is included. Reviewers commonly describe receiving:
- Compounded GLP-1 vial(s)
- Insulin syringes
- Alcohol wipes
- Written injection instructions
Patients consistently mention the packaging quality: “My medication arrived on ice. The package was complete with all syringes and alcohol wipes needed for three months. Complete with detailed instructions.”
Your First Injection
If you've never self-injected before, the idea sounds intimidating. Almost every Yucca reviewer who mentions this says the same thing: it was far easier than expected.
One Trustpilot reviewer: “I was very concerned about administering the medication but it's a lot easier than I imagined and I've experienced zero pain whatsoever with the injection.”
You inject once per week, subcutaneously (just under the skin — stomach, thigh, or upper arm). The needle is small. The onboarding team walks you through it on your welcome call, and you can message your provider through the portal anytime.
The Onboarding Call — Why Patients Keep Talking About It
This deserves its own mention because it's the single most-praised feature in Yucca's Trustpilot reviews. Within a day or two of receiving your medication, a member of Yucca's care team calls you. Not a robot. Not a chatbot. A real person.
They walk you through:
- How to use your patient portal
- Your medication and what to expect
- Your dosing schedule
- How to reach your provider
- Tips for managing early side effects
- Any questions you have
The names come up over and over in reviews: Hazel, Johann, Rachelle, Sam, Honey, Joanna, Lucky. Patients describe them as “friendly,” “bubbly,” “knowledgeable,” “patient.” One reviewer gave the customer service a rating of “10,393,872 out of 10.”
This is genuinely unusual in the telehealth GLP-1 space. Most competitors give you an app and wish you luck. Yucca gives you a human being who actually picks up the phone. If you're new to GLP-1 medication and the whole process feels overwhelming, this alone might be worth choosing Yucca.
Yucca Health Pricing: What You'll Actually Pay
This is the section most other Yucca Health reviews get wrong — either vague about the numbers or they only show the introductory price without mentioning what happens next. We're going to show you both.
Published Pricing (New Patients)
Yucca publishes these prices for patients who are new to GLP-1 medication. The key detail most reviews miss: longer plans are billed upfront for the full period, not monthly. That's how you get the lower per-month rate — you're committing to the full term.
Semaglutide Pricing:
| Plan | First Order | Standard Ongoing Rate | Billed How |
|---|---|---|---|
| Monthly | $175 | $275/mo | Every month |
| 3-Month | ~$165/mo equiv. | ~$255/mo equiv. | Every 3 months |
| 6-Month | $146/mo equiv. | ~$206/mo equiv. | Every 6 months |
Tirzepatide Pricing:
| Plan | First Order | Standard Ongoing Rate | Billed How |
|---|---|---|---|
| Monthly | $285 | $385/mo | Every month |
| 3-Month | ~$265/mo equiv. | ~$355/mo equiv. | Every 3 months |
| 6-Month | $258/mo equiv. | ~$325/mo equiv. | Every 6 months |
Pricing from Yucca's semaglutide and tirzepatide product pages as of March 2026. Confirm your exact charge during checkout — verify the billing cadence before you commit.
What Happens After the First Order
Here's what most reviews don't tell you: your rate increases after the introductory first order. On the 6-month semaglutide plan, that means going from $146/mo equivalent to approximately $206/mo equivalent.
Why does the price go up? Two reasons. First, the introductory rate is a new-patient promotional price. Second, as your provider increases your dose over time (standard GLP-1 titration — you start low and work up), higher doses typically cost more. This is standard across the entire compounded GLP-1 industry, not unique to Yucca.
But here's why it still works: even at the higher ongoing rate, Yucca's 6-month semaglutide plan ($206/month) is still dramatically cheaper than brand-name Wegovy without insurance ($1,000+/month retail). And unlike Ro, there's no additional $145/month membership fee on top of your medication cost.
What's Included in the Price
Everything. No hidden fees.
- Telehealth consultation and provider review
- Compounded medication (full supply, 4 weekly injections)
- Injection supplies (syringes, alcohol wipes)
- UPS 2-Day Air temperature-controlled shipping
- Personal onboarding call with care team
- Patient portal access
- Ongoing provider messaging and dose management
What is NOT included
Insurance billing, itemized HSA/FSA receipts, or letters of medical necessity.
Can You Use HSA or FSA?
Yes — many patients use HSA/FSA cards to pay. However, Yucca states they do not provide itemized receipts or letters of medical necessity, which means your HSA/FSA administrator may or may not accept the charge. Check with your specific plan before counting on this.
How Yucca's Cost Compares
| Provider | Semaglutide Starter | Additional Fees | Model |
|---|---|---|---|
| Yucca Health | From $146/mo equiv. | No membership fee | Compounded, cash-pay |
| Hims & Hers | From $199/mo | No membership fee | Compounded, cash-pay |
| Ro (Body Program) | Varies by med | $45 first mo, then $145/mo membership | Brand-name + insurance focus |
| Brand-name Wegovy (self-pay) | Varies; intro offers from ~$199/mo at low doses | N/A | FDA-approved |
Pricing from provider websites as of March 2026. Brand-name self-pay pricing varies by dose and promotional period — check current offers directly.
Yucca has one of the lowest published semaglutide starter prices among the compounded providers we reviewed, and it doesn't layer a separate membership fee on top. That's a meaningful difference when you're budgeting for treatment that lasts months.
No Membership Fee · No Charge Until Approved
See current Yucca pricing and check your eligibility
Semaglutide from $146/mo (6-month plan). Tirzepatide from $258/mo. You're only charged if a licensed provider approves your treatment.
See Current Yucca Pricing and Check Your Eligibility →Is Yucca Health Legit? What We Verified (And What We Couldn't)
This is the question that brought you here. Let's answer it with evidence, not opinions.
Yucca Health Verification Audit
We built this table so you can see exactly what we checked and what the evidence shows. No other Yucca review page does this.
| What We Checked | Verified? | Notes |
|---|---|---|
| Real business entity with address | ✓ Yes | Brand Merchants Network LLC, 9350 Wilshire Blvd Suite 203, Beverly Hills CA 90212 |
| Working phone number | ✓ Yes | (888) 388-1878 |
| Named, licensed physicians | ✓ Yes | Dr. Michael Wasef, MD (board-certified Internal Medicine), Dr. Frank Suppa, DO, Dr. Andrew Sakla, DO |
| Licensed U.S. pharmacies | ✓ Stated | Yucca states meds are compounded by licensed U.S. pharmacies |
| HIPAA compliance | ✓ Stated | Published Notice of Privacy Practices with PHI rights |
| Published Terms of Service | ✓ Yes | Full terms publicly available at tryyucca.com |
| Published refund policy | ✓ Yes | No refunds once shipped; exceptions for billing errors |
| Trustpilot presence with real reviews | ✓ Yes | ~909 reviews, 4.6/5, company responds to reviews including negative ones |
| FDA compliance disclosure | ✓ Yes | Explicitly states compounded meds are not FDA-approved |
| You're only charged if approved | ✓ Stated | Temporary hold drops if provider does not approve |
| Specific pharmacy names | ✗ Not public | Yucca does not publicly disclose partner pharmacy names |
| 503A vs 503B pharmacy status | ✗ Not confirmed | Could not determine from public pages |
| Dose-escalation pricing schedule | Partial | Intro pricing published; escalation rates confirmed during intake |
What We Could Verify ✓
Real business entity. Yucca Health operates as Brand Merchants Network LLC (d/b/a Yucca Health), with a published address at 9350 Wilshire Blvd, Suite 203, Beverly Hills, CA 90212. They have a working phone number: (888) 388-1878. And a working email: hello@tryyucca.com.
Named, licensed physicians. Yucca's site lists Dr. Michael Wasef, MD, as a board-certified Internal Medicine physician “licensed nationwide.” It also lists Dr. Frank Suppa, DO, and Dr. Andrew Sakla, DO, as clinical team members. These are verifiable credentials.
Licensed U.S. pharmacies. Yucca states medications are compounded by licensed U.S. pharmacies following compounding standards. Yucca uses a state-licensed pharmacy network.
HIPAA compliance. The platform uses encrypted data handling with a published Notice of Privacy Practices covering your rights to access, amend, and receive breach notifications for your protected health information.
Published policies. Yucca has public Terms of Service, Privacy Policy, Refund Policy, Shipping Policy, Consent to Telehealth, and a Physician Code of Conduct. This is more transparent than many competitors.
Active Trustpilot presence. About 909 reviews, 4.6/5 rating, and Yucca responds to virtually every review — including negative ones. Trustpilot's policies state that companies cannot pay to hide reviews.
Clear FDA compliance disclosures. Yucca explicitly states on their safety pages that compounded medications “are not FDA-approved and do not undergo FDA review for safety, effectiveness, or manufacturing quality.” The fact that they disclose this prominently is actually a trust signal — many competitors bury or omit this information.
What We Could Not Verify From Public Information
Transparency means telling you what we don't know, too:
- Specific partner pharmacy names — Yucca does not publicly list which compounding pharmacies they use. You can ask their support team directly.
- Whether their pharmacies operate under 503A or 503B — we could not confirm this from public pages. This is a regulatory distinction that affects compounding authority.
- Exact pricing for dose escalation — while we've documented the published intro and standard rates, individual pricing at higher doses may vary and is confirmed during intake.
Our assessment
Based on everything we could verify — named physicians, physical business address, extensive Trustpilot history with company responses, published policies, and transparent FDA disclosures — Yucca Health operates as a legitimate telehealth platform. It is not a scam.
What 900+ Trustpilot Reviews Actually Say About Yucca Health
Instead of cherry-picking five-star quotes, we looked for patterns. Here's what real patients consistently report.
What Patients Praise Most
The onboarding experience. This comes up in review after review. Patients don't just say “good service” — they name specific people. Hazel, Johann, Rachelle, Sam, Honey, Joanna, Lucky. Reviewers describe phone calls where a team member walks them through the portal, explains their medication, answers every question, and follows up.
“I did a lot of research before choosing Yucca Health. Reviews were mixed but something just led me to trust them. I have zero regrets. I lost 25 lbs in almost 3 months.”
— Trustpilot reviewer
“Many companies out there have hidden membership fees and costs. I came back to Yucca.”
— Trustpilot reviewer
“My medication arrived on ice. The package was complete with all syringes and alcohol wipes needed for three months. Complete with detailed instructions.”
— Trustpilot reviewer
Speed. Fast approval and fast shipping are mentioned constantly. “Got the medication like two days after signing up.” “Approved quickly and my vials shipped later the same day.”
No hidden fees. “No extra fee — what you see is what you pay.” Patients who've shopped around specifically cite Yucca's lack of a separate membership fee as a differentiator.
Affordability. “Yucca Health offered the most reasonable option.” “The price is one of the best on the market.”
What Patients Complain About
Billing confusion around dose changes. Some patients report unexpected charges when their dose increases. One reviewer signed up at $146 and was charged $275 on a subsequent order. As we covered in the pricing section, this is likely dose-escalation pricing — standard in the industry, but it catches people off guard when they haven't been clearly warned.
Customer service response time. Several reviews mention that support replies can be slow, especially by phone. Yucca is a portal-first communication platform — email and portal messaging are the primary support channels. If you strongly prefer phone-based support, this is worth knowing.
Strict refund policy. A few patients express frustration that they couldn't return medication after it shipped. This is directly stated in Yucca's policies — compounded medications are custom-prepared and cannot be returned.
What This Tells You
The pattern is clear: Yucca's strengths are price, speed, and personal onboarding. Their weaknesses are billing clarity on dose changes and limited refund flexibility after shipping. The negative reviews represent a small minority of the 900+ total, and the complaints follow patterns we see across every GLP-1 telehealth provider — they're not unique red flags.
Notably, Yucca consistently responds to negative reviews on Trustpilot, typically within 48 hours. That's more accountability than most competitors show.
A Note About Review Counts You'll See Elsewhere
If you've been searching around, you may have noticed conflicting review numbers for Yucca Health. One currently ranking page claims Yucca has “24,711 satisfied customers” with a 4.8-star average. Another says 36,000+ votes. Yucca's own website says “20,000+ happy patients.”
The verifiable third-party number — Trustpilot — shows approximately 900 reviews with a 4.6/5 rating as of this writing. The other numbers likely reference internal patient counts, social media engagement, or other metrics we cannot independently verify.
We use the Trustpilot number throughout this page because it's the one we can actually verify.
What Negative Reviews Look Like vs. Actual Scam Patterns
Yucca's negative reviews are about service friction, not fraud. People complain about billing confusion, slow support replies, and strict refund policies. They do not complain about never receiving medication, fake products, stolen credit card information, or total non-communication.
Compare that to actual telehealth scam patterns, which typically involve: no real company address, no named physicians, no response to any complaints, complete disappearance after payment, fake Trustpilot profiles with no company responses.
Yucca has a verified Beverly Hills address, named board-certified physicians, responds to Trustpilot reviews consistently (including 1-star ones), and has 900+ reviews built up over time. That's the profile of a legitimate company with some service friction — not a scam operation.
Are Compounded GLP-1 Medications Safe? What You Need to Know
What “Compounded” Actually Means
Compounded semaglutide and tirzepatide are prescription medications prepared by licensed U.S. pharmacies for individual patients based on a licensed provider's prescription.
They are not FDA-approved as finished products. This means the specific compounded preparation has not gone through the FDA's full clinical trial review process for safety, efficacy, and manufacturing quality the way brand-name Wegovy or Zepbound have.
Compounding under Section 503A of the Federal Food, Drug, and Cosmetic Act is a regulated practice — when done with a patient-specific prescription from a licensed provider and prepared by a licensed pharmacy, it is a legal pathway to prescription medication.
The FDA's Current Position
The FDA resolved the semaglutide shortage in February 2025 and the tirzepatide shortage in late 2024. In February 2026, the FDA announced its intent to take action against non-FDA-approved GLP-1 products being mass-marketed as alternatives to approved drugs.
The regulatory environment around compounded GLP-1 access tightened in 2025–2026. Legal cases between compounding industry groups and the FDA are still being litigated. For now, these programs remain operational and continue to serve patients.
What this means for you practically
Compounded GLP-1 programs like Yucca operate under a regulatory framework that's evolving. Yucca's model uses licensed providers writing patient-specific prescriptions filled by licensed pharmacies. If the FDA further restricts compounded GLP-1 access, it would affect Yucca and every similar platform.
When Brand-Name Is the Better Choice
If any of these apply, you should consider the brand-name route instead:
- Your insurance covers Wegovy or Zepbound with a manageable copay
- You specifically want FDA-approved finished medication with full clinical trial backing
- You have a complex medical history that warrants the most studied formulation
For everyone else — cash-pay patients comparing compounded options because brand-name pricing remains significantly higher — programs like Yucca represent one of the most accessible paths to GLP-1 treatment available right now.
Learn more: How to get an FDA-approved GLP-1 · Cheapest tirzepatide without insurance (2026)
No charge until a licensed provider approves your treatment
Side Effects: What Yucca Health Patients Actually Experience
GLP-1 medications come with side effects. That's true whether you're taking brand-name Wegovy from a pharmacy or compounded semaglutide through Yucca. Here's what to realistically expect.
Common Side Effects (Most Patients Experience Some of These)
- Nausea — the most commonly reported side effect, especially in the first 2–4 weeks. Multiple Trustpilot reviewers describe it as manageable: “The nausea which I was well aware is a common side effect... honestly it's not that bad, just a bit of a nuisance.”
- Reduced appetite — this is the medication working as intended
- Constipation or diarrhea
- Headache
- Fatigue
- Mild injection site reactions
Yucca's providers start you on a low dose and gradually increase it over time specifically to minimize these side effects. The titration approach means your body has time to adjust.
Serious Side Effects (Rare but Important)
Per the FDA-approved labeling for semaglutide and tirzepatide:
- Boxed warning: Risk of thyroid C-cell tumors has been observed in animal studies. Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use these medications.
- Pancreatitis — seek medical attention for severe, persistent abdominal pain
- Gallbladder problems
- Kidney injury (usually related to dehydration from GI side effects)
- Severe allergic reactions
These risks are documented in the FDA-approved labeling for branded semaglutide and tirzepatide products and represent class-level safety concerns for GLP-1 medications. Yucca's providers review your medical history for contraindications before approving treatment.
Additional cautions from Yucca's safety pages
Semaglutide and tirzepatide are not recommended during pregnancy or breastfeeding. Patients with severe gastrointestinal conditions such as gastroparesis should use these medications carefully or avoid them.
Learn more: GLP-1 hard contraindications — who should not take these medications
Yucca Health vs. the Main Alternatives
If you're comparison shopping — and you should be — here's how Yucca stacks up.
Yucca vs. Hims & Hers
Hims offers compounded semaglutide starting at $199/month on their 6-month plan. That's $53 more per month than Yucca's starter price. Hims also offers oral weight loss medication kits as an alternative to injectables, which Yucca doesn't.
Pick Yucca if you want the lowest semaglutide price and value personal onboarding support. Pick Hims if you want oral medication options or the comfort of a large, well-known consumer brand.
Yucca vs. Ro
Ro operates differently. Their Body Program charges a membership fee ($45 first month, then $145/month) on top of medication costs and focuses primarily on helping patients access brand-name medications through insurance.
Pick Yucca if you're paying cash and don't want a membership fee layered onto your medication cost. Pick Ro if you have insurance that might cover brand-name Wegovy or Zepbound and want help navigating prior authorization.
Full Comparison: Yucca vs. Major Alternatives
| Feature | Yucca Health | Hims & Hers | Ro |
|---|---|---|---|
| Semaglutide starting price | $146/mo (6-mo plan) | $199/mo (6-mo plan) | Membership + med cost |
| Tirzepatide starting price | $258/mo (6-mo plan) | Not widely offered | Varies |
| Membership fee | None | None | $45 first mo, $145/mo after |
| Medication type | Compounded | Compounded | Brand-name (insurance) |
| Oral options | No (injectable only) | Yes | No |
| Onboarding experience | Personal phone call | App-based | App-based |
| Provider model | Async review, portal messaging | Async review | Async + app |
| Trustpilot | ~4.6/5 (~909 reviews) | Varies | Varies |
| Refund after shipping | No | Varies | Membership cancellable |
| Shipping | UPS 2-Day Air | Standard | Standard |
| Insurance accepted | No | No | Yes (brand-name path) |
| HSA/FSA | Yes (no itemized receipts) | Yes | Yes |
Pricing from provider websites as of March 2026. Ratings and pricing subject to change.
Why the “No Membership Fee” Detail Matters More Than You Think
Some platforms advertise low medication prices — but then add a required monthly membership fee on top. Ro charges $145/month just for platform access, before your medication cost. Over six months, that's roughly $770 in membership fees alone before you've paid for a single dose. With Yucca, that $770 stays in your pocket.
Lowest Published Semaglutide Price · No Membership Fee
See current Yucca pricing and check your eligibility
No enrollment fee. No consultation fee. No platform fee. What you see is what you pay. Charged only if approved by a licensed provider.
Check Current Yucca Pricing and Eligibility →Shipping, Support, and What Happens After You Order

Approval Speed
Yucca states provider review typically happens within 24 hours. Based on Trustpilot reviews, many patients report same-day or next-day approval. The review is asynchronous — your provider reads your intake and either approves, follows up with questions through the portal, or declines. No video call required unless the provider specifically requests one.
Shipping Details
- Carrier: UPS 2-Day Air
- Shipping days: Monday through Friday only (cold-chain integrity — medications need temperature control)
- Packaging: Temperature-controlled, arrives on ice
- Tracking: You receive a tracking number by email when your order ships (tracking typically activates within 24 hours)
- Delivery: To your doorstep. Someone should be available to receive it promptly since these meds need refrigeration upon arrival.
Ongoing Support
After your onboarding call, you're not on your own. Yucca provides:
- Patient portal for messaging your provider and care team
- Dose titration management — your provider adjusts your dose over time
- 24/7 customer service availability (primarily portal/email-based)
- Progress tracking through the patient portal
If you need to reach them directly: phone at (888) 388-1878, email at hello@tryyucca.com, or through the patient portal.
Cancellation and Refund Policy: What to Know Before You Commit
This is where you need to go in with eyes open. We're not going to sugarcoat it — but we'll give you the full context.
The Refund Policy
Compounded medications are custom-prepared. Once they've been made and shipped for you, they cannot be returned or refunded. This is Yucca's stated policy, and it's standard across compounded pharmacy services.
Refunds are only available for:
- Billing errors
- Duplicate charges
- Provider non-approval (you were charged but shouldn't have been)
Auto-Renewal and Early Billing
Subscriptions auto-renew. Your card is charged 5–7 days before your next shipment date — this gives the provider time to review your chart and the pharmacy time to compound. Put a calendar reminder before your renewal date if you want to make changes.
How to Protect Yourself
- Start with a shorter plan if you're unsure. The monthly plan costs more per month, but it gives you flexibility to test the service before committing to 3 or 6 months.
- Mark your renewal dates. If you want to pause or cancel, do it at least 7+ days before your next billing cycle.
- Read the full Terms of Service on tryyucca.com before completing checkout.
The Smart Way to Start If You're Nervous
If the refund policy makes you hesitate (which is totally reasonable), here's the approach we'd recommend:
Start with the monthly plan — Yes, it costs more per month (~$175 for semaglutide vs. $146 on the 6-month plan). But you're only committing to one month. Think of the extra $29 as insurance on your peace of mind.
Use the first month to evaluate everything — The onboarding experience, medication quality, how you feel, whether the support team is responsive, whether the portal works for you.
If you love it, switch to a longer plan — Lock in better pricing for month two. Based on the Trustpilot data, most patients who try one month end up staying.
If it's not for you, you've only committed one month — Not six. This completely eliminates the 'what if I hate it and I'm locked in' anxiety.
What Results Can You Realistically Expect?
Let's set honest expectations. Because what actually happens when you start GLP-1 medication matters a lot more than hype.
The Clinical Evidence
- The STEP-1 trial (semaglutide, New England Journal of Medicine, 2021) showed participants lost an average of approximately 15% of their body weight over 68 weeks when combined with lifestyle changes.
- The SURMOUNT-1 trial (tirzepatide, NEJM, 2022) showed participants on the highest dose lost an average of approximately 22.5% of their body weight over 72 weeks.
These results were achieved with specific doses of FDA-approved branded medications in controlled clinical settings. Individual results with any GLP-1 program — including Yucca — will vary.
What Yucca Patients Report
25 lbs
in under 3 months
30 lbs
over one year
38 lbs
in 5 months
15 lbs
in first 3 months
Individual results from Trustpilot reviewers. Results vary.
The Realistic Timeline
- Weeks 1–4: Reduced appetite and cravings. Some initial weight loss (2–5 lbs is common). You're on the lowest dose during this period. Some nausea — temporary, fades within the first couple of weeks.
- Weeks 4–12: More meaningful weight loss begins as your dose increases. Most patients notice significant changes in how their clothes fit, energy level, and relationship with food.
- Months 3–6: Where the most significant results happen for most people, especially when combined with better nutrition and movement. Trustpilot reviewers in this window report 15–40+ pounds lost.
- 6+ months: Continuing progress. Dose may stabilize. The lifestyle changes you've been building start to feel automatic rather than forced.
What Changes Beyond the Scale
Something patients mention that rarely makes it into review summaries:
“I finally feel comfortable taking photos”
“I'm hiking again and enjoying life in ways I never thought I would”
“My confidence is higher and I feel stronger during workouts”
“The constant mental battle finally got quieter, and I feel more like myself again”
“My energy is better, my clothes fit again”
An Honest Word About Sustainability
GLP-1 medication is powerful. But it works best as part of a bigger picture. The patients who get the best long-term results are the ones who use the appetite reduction as a window to build sustainable habits — better nutrition, regular movement, sleep, hydration. The medication gives you the breathing room to make those changes without fighting your own biology.
4.6/5 Trustpilot · No Charge Until Approved
Start your free eligibility check on Yucca Health
The intake takes about five minutes. If a licensed provider doesn't approve you, you're not charged. No commitment until a real provider says yes.
Start Your Free Eligibility Check on Yucca Health →Semaglutide or Tirzepatide: Which Should You Choose on Yucca?
This is one of the first decisions you'll make during Yucca's intake, so let's make it easy.
Semaglutide
- Works on one receptor pathway (GLP-1)
- More clinical data available as a drug class
- Not FDA-approved as compounded — not brand-name Ozempic or Wegovy
- Yucca price: From $146/mo (6-month plan)
- Good for: First-time GLP-1 users, budget-conscious patients
Tirzepatide
- Works on two receptor pathways (GLP-1 and GIP)
- Branded trials showed potentially greater weight loss at higher doses
- Not FDA-approved as compounded — not brand-name Mounjaro or Zepbound
- Yucca price: From $258/mo (6-month plan)
- Good for: Patients willing to pay more for potentially stronger appetite suppression
First-Term Cost Comparison (6-Month Plan)
| Plan Period | Semaglutide (6-Mo Est.) | Tirzepatide (6-Mo Est.) |
|---|---|---|
| First billing period | ~$146/mo equiv. | ~$258/mo equiv. |
| Ongoing rate (months 2–6) | ~$206/mo equiv. | ~$325/mo equiv. |
| Estimated 6-month total | ~$1,176 | ~$1,883 |
Remember: 6-month plans are billed for the full period upfront, not month by month. These are estimates — confirm during checkout.
If cost is your primary factor and budget is the main constraint: semaglutide is the lower-cost entry point. The actual choice should be made with your provider based on your medical history, tolerance, and goals — Yucca's providers manage these decisions during your treatment.
Learn more: Best GLP-1 for weight loss: Zepbound vs Wegovy comparison
How We Researched This Page
We believe you should know exactly where our information comes from and what our process looked like.
Sources we reviewed:
- Yucca Health's website: pricing pages, FAQ, safety information, Terms of Service, refund policy, shipping policy, and consent to telehealth pages (tryyucca.com)
- 900+ Trustpilot reviews: analyzed for patterns in both positive and negative feedback, response rates, and review distribution
- Reddit threads and forum discussions about Yucca Health
- FDA.gov: regulatory guidance on compounded GLP-1 medications, safety advisories, shortage status updates
- Published clinical trial data (STEP-1, SURMOUNT-1) from peer-reviewed journals
- Competitor websites: Hims, Ro, MEDVi — pricing pages and terms for comparison
- Yucca Health's listed physicians: Dr. Michael Wasef, MD; Dr. Frank Suppa, DO; Dr. Andrew Sakla, DO — credentials referenced from published site information
Our evidence hierarchy:
- Official Yucca policy/pricing pages — primary source for what Yucca offers and claims
- FDA/clinical trial data — standard for medical safety and efficacy information
- Trustpilot (third-party review platform) — most reliable third-party patient experience data
- Reddit/forums — useful for surfacing common concerns, but anecdotal
- Company marketing claims — labeled as company-stated, not independently verified
What this page is not: We did not sign up for Yucca, receive medication, or test the product firsthand. This review is based on publicly available information and third-party patient data. Key factual claims are sourced inline throughout the page. Where we give opinions, we label them clearly.
Affiliate Disclosure: The RX Index may receive a commission if you sign up through links on this page. This does not influence our analysis, methodology, or recommendations. We recommend providers we would genuinely tell a friend about. If Yucca isn't right for your situation, we say so — and we point you to what is.
Yucca Health GLP-1 Reviews: Frequently Asked Questions
Is Yucca Health legit?
Is Yucca Health a scam?
Is Yucca Health the same as the yucca supplement on WebMD?
Are Yucca Health's GLP-1 medications FDA-approved?
How much does Yucca Health semaglutide cost?
How much does Yucca Health tirzepatide cost?
Does Yucca charge before you're approved?
Does Yucca Health accept insurance?
How fast does Yucca Health ship?
Can you cancel Yucca Health?
Does Yucca Health offer tirzepatide?
Who are Yucca Health's doctors?
Does Yucca Health ship to all 50 states?
What do Reddit users say about Yucca Health?
What do Trustpilot reviews say about Yucca Health?
Is there a Consumer Reports review of Yucca Health?
Is Yucca better than Ro or Hims?
Semaglutide or tirzepatide — which should I choose on Yucca?
Does Yucca Health auto-renew?
What BMI do I need to qualify for Yucca Health?
Is Yucca Health available for men and women?
How do I store my Yucca Health medication?
The Bottom Line: Should You Try Yucca Health?
You've read the pricing — both the introductory rate and what comes after. You've seen what 900+ real patients report. You've read the fine print that nobody else bothered to show you. You've seen the comparison against every major alternative.
Here's where we land.
Yucca Health is one of the most affordable compounded GLP-1 telehealth options we've reviewed for 2026. It has one of the lowest published semaglutide starter prices among the providers we compared, no membership fee, and a personal onboarding experience that patients genuinely love.
Is it perfect? No. The refund policy is strict. The ongoing pricing after your intro period is higher than the headline number. Customer support leans toward portal messaging over phone calls. And the medications are compounded — not FDA-approved finished drugs.
“I told myself it was too expensive. I told myself I didn't deserve the help. I told myself I should just try harder. But starting with Yucca Health didn't just change my physical progress — it completely changed my mindset. The constant mental battle finally got quieter, and I feel more like myself again.”
— Yucca Health patient, TrustpilotSo Who Should Pull the Trigger?
You're paying out of pocket (no GLP-1 insurance coverage)
You're comfortable with compounded medication
You want the lowest possible price without hidden membership fees
You'd appreciate a real person calling to walk you through everything
You've done your research (you're doing it right now) and you're ready
If that's you — you've done the work. You've read more about Yucca Health's pricing, policies, and patient experiences than the vast majority of people who sign up. You know the costs. You know the tradeoffs. You know who it's for and who it's not for.
The intake takes about five minutes. You pick your medication and plan. A licensed provider reviews your medical history. If they approve you, your medication ships via UPS 2-Day Air. If they don't approve you, you're not charged. The commitment starts only after a real provider says yes.
4.6/5 Trustpilot · 909+ Reviews · No Charge Until Approved
Check your eligibility on Yucca Health — you're only charged if approved
Free health assessment. Semaglutide from $146/mo (6-month plan). Tirzepatide from $258/mo. UPS 2-Day Air shipping. Personal onboarding call included.
Check Your Eligibility on Yucca Health →Related Guides
Medical Disclaimer: This content is for informational purposes only and is not medical advice. Consult a qualified healthcare professional before starting any medication. GLP-1 medications are prescription drugs with potential side effects and contraindications. Compounded medications are not FDA-approved finished products.
Editorial Standards: The RX Index maintains published editorial standards for all reviews. Read our full methodology →