Weight Regain After Stopping Wegovy: What Really Happens — and What to Do Next

By The RX Index Editorial Team · Last verified: May 30, 2026 · Next pricing check: June 30, 2026

The RX Index is a pricing intelligence and comparison resource for GLP-1 telehealth providers. This page is education, not medical advice — always talk to your own clinician before changing your treatment. Some links are affiliate links, and we may earn a commission if you use them. That never changes what we recommend or what we report.

Yes — weight regain after stopping Wegovy is common. But it is not a personal failure, it is not instant, and it is not the whole story. The scary number you’ve probably seen — that people regain “two-thirds” of their lost weight — comes from a clinical trial where everyone stopped all support at the same time. In real life, most people don’t do that. So most people don’t regain like that, either.

In the big Wegovy trial (STEP 1 extension), people who stopped the medicine and kept going on willpower alone regained about two-thirds of their lost weight within a year. But in one of the largest real-world studies to date — a 2026 Cleveland Clinic analysis of nearly 8,000 adults — people treated for obesity regained only about 0.5% of their body weight on average a year after stopping, and about 45% kept losing or stayed the same. Why the huge gap? Because in real life, many people taper, switch, or restart.

The two numbers that explain everything

Most pages show you one number and let you panic. We’re going to show you both, because the truth lives in the gap between them.

	If you stop cold (the trial number)	What usually happens in real life
Source	STEP 1 extension trial, 2022 + Oxford/BMJ review, 2026	Cleveland Clinic real-world study, 2026
What it measures	People who stopped the drug and stopped support	What nearly 8,000 real patients actually did
Weight regain	About two-thirds of lost weight back within a year; roughly 0.8 kg (1.8 lb) per month for drugs like Wegovy	About 0.5% of body weight regained on average after a year (people treated for obesity)
Kept their loss?	Most regained a lot	About 45% kept losing or stayed the same
Why	The medicine’s appetite control fades and nothing replaces it	Many tapered, switched, or restarted — about 27% moved to a different medication

The takeaway: The frightening stat is real, but it’s the worst-case path — stopping everything at once. The reassuring stat is also real, and it’s the path most people actually walk. You get to choose which one is more likely for you. That choice is what the rest of this page is about.

Not sure which path is yours? Take our free 60-second quiz and get a personalized GLP-1 action plan — based on why you’re stopping and what fits your life.

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How much weight regain after stopping Wegovy should you expect?

Answer: On average, people regain a large share of the weight they lost after stopping Wegovy, because semaglutide only controls appetite while you take it. In the STEP 1 extension trial, people regained about two-thirds of their lost weight within one year. But a trial average is not a prediction for any one person — real-world results are often much gentler, especially for people who keep some form of treatment or support going.

The trial number: about two-thirds, fairly fast

The most-quoted study is the STEP 1 extension (published in Diabetes, Obesity and Metabolism, 2022). People lost about 17% of their body weight on semaglutide. Then everyone stopped the medicine and the structured lifestyle program at the same time. A year later, they had regained about two-thirds of what they’d lost — though they were still a bit below where they started.

A newer review backs this up. In 2026, researchers at the University of Oxford pooled 37 studies of more than 9,000 people (published in The BMJ). They found that after stopping weight-loss drugs, people regained about 0.4 kg (roughly 0.9 lb) per month on average — and for newer drugs like semaglutide and tirzepatide, the rate was faster, about 0.8 kg (1.8 lb) per month. At that pace, many people would drift back toward their starting weight over about a year and a half. So if you stop and change nothing else, gaining weight back is the likely outcome.

The real-world number: often far less

In 2026, Cleveland Clinic published one of the largest real-world studies on this exact question — also in Diabetes, Obesity and Metabolism — following nearly 8,000 adults. Among people treated for obesity, the average weight loss before stopping was 8.4%. One year after stopping, they had regained only about 0.5% of their body weight on average. About 45% kept losing or stayed the same.

Why so different from the trials? The researchers were clear: many people don’t truly “stop.” About 27% switched to a different medication, and others restarted the original drug or stepped down to a lower dose. Real-world patients also lost a bit less to begin with, so they had less to regain. And the most common reason people stopped in the first place was cost — not failure.

So which number is “true”?

Both. The trials show what happens when you remove everything at once. Real life shows what happens when people keep managing it. The gap between them is the plan you make. That’s genuinely good news, because a plan is something you can control.

Why does the weight come back — is it my fault?

Answer: No. Weight regain after stopping Wegovy reflects biology, not weak willpower. Obesity is a long-term, relapsing condition, and the body actively defends a higher weight by turning hunger back up once the medication that quieted it is gone. The people who do best treat regain as a signal to adjust the plan — not as proof they failed.

Wegovy works by acting like a natural gut hormone called GLP-1 (glucagon-like peptide-1 — a hormone that tells your brain you’re full and slows how fast your stomach empties). While the drug is in you, hunger goes quiet. Many people call this the return of “food noise” — the constant background chatter about food that finally went silent on the medicine.

When you stop, the drug fades, and that food noise comes back. Cravings return. Portions creep up. Your body, which spent years “set” to a higher weight, starts pulling you back there. None of that is a character flaw. It’s the same biology that made losing weight hard in the first place.

The same 2026 BMJ review found that improvements in blood pressure, blood sugar, and cholesterol also tend to drift back toward where they started within about a year and a half of stopping. That’s one more reason the decision to stop is worth making with your provider, not alone.

Is this “withdrawal”?

Not in the usual sense of the word. Wegovy’s FDA label does not describe a dependence-style withdrawal syndrome. What most people call “withdrawal” is usually the return of appetite, cravings, and food noise as semaglutide leaves your system.

How long does Wegovy stay in your system — and when does the weight come back?

Answer: Weight regain after Wegovy is gradual, not overnight. Semaglutide has a half-life of about one week and stays in your body for roughly 5 to 7 weeks after your last dose, so appetite returns slowly over that window. Regain is measured over weeks and months; the 2026 BMJ review found newer drugs like semaglutide averaged about 0.8 kg (1.8 lb) per month after stopping, though individual timing varies.

Time since last dose	What’s happening inside	What you may notice
Week 1–2	Drug is still mostly active	Little change; appetite still calm
Week 2–5	Levels falling	Hunger and food thoughts slowly returning
Week 5–7	Drug nearly cleared	Appetite back near where it was before; this is when a written plan matters most
Beyond week 7	Drug is essentially gone	Weight may climb if eating rises with appetite; the rate varies a lot person to person

One important nuance: “Still in your system” is not the same as “still working.” The drug can be detectable for weeks while its appetite-control effect has already faded. So don’t be surprised if hunger returns before the calendar says the drug is fully gone.

Can you stop Wegovy without gaining the weight back?

Answer: Some people keep most of their loss after stopping, but the average pattern in trials is regain — so the realistic goal isn’t “never gain a pound.” It’s to slow regain, catch it early, and decide in advance what would prompt you to act. People who hold their results almost always keep doing something: a lower dose, a switch, a restart when needed, or strong ongoing habits and support.

The hard truth: if you stop Wegovy completely and go back to relying on willpower alone, the odds are you’ll regain a meaningful amount — sometimes most of it. That’s exactly what the trials and the Oxford review show.

But that’s the worst-case version, and it’s not the version most real people live. Remember the Cleveland Clinic data: about 45% kept losing or stayed the same. The people who succeed share one habit — they don’t just stop and hope. They make a plan before the medicine wears off.

Based on the evidence, a few things stand out:

Keeping some treatment going — a lower maintenance dose, a switch, or a clear plan to restart — is the single biggest difference between the scary number and the reassuring one.
Building habits while the drug still helps. Appetite is easier to manage now than it will be in two months. Make protein a priority at meals, keep moving, and protect your sleep. Don’t crash-diet — that tends to backfire.
Strength training matters. One 2024 analysis (a Danish study using an older GLP-1 medicine, liraglutide) found that adding supervised exercise helped people keep weight off better after treatment than the medicine alone. Keep muscle, keep moving.
A realistic definition of success. Keeping even half of your loss, avoiding rapid regain, and protecting your blood pressure and blood sugar is a real win. Perfection isn’t the bar.

Should you stop, lower your dose, switch, or stay on Wegovy?

Answer: Wegovy’s label includes rules for dosing, missed doses, and switching between the shot and the pill — but it does not give a formal “taper off” schedule. The better question isn’t how to stop; it’s whether to stop, lower your dose, switch, or stay on — and that depends on why you want off in the first place.

Path	Best fit for	Main trade-off
Stay on a maintenance dose	You hit your goal, tolerate the medicine, and can afford it	Ongoing cost and staying on medication
Lower or adjust the dose	Side effects, or you want the lowest dose that holds your weight	Must be done with your provider, not on your own
Switch (pill, different drug, or different provider)	Injection fatigue, access, or cost is the real problem	Still needs a prescription and eligibility
Stop, with a real off-ramp plan	Pregnancy, surgery, cost, or a personal choice	Regain risk is real — the plan is what protects you

Notice that “stop cold and hope” isn’t on the list. That’s the one path the data tells us to avoid. One label fact worth knowing: for adult weight management, the Wegovy injection maintenance dose is either 1.7 mg or 2.4 mg once weekly, and the label says your provider should weigh how you respond and how well you tolerate it when choosing your dose. So you don’t always have to pick between the full dose and nothing — but never change your dose on your own.

Why are you stopping? Find your situation

Answer: “Stopping Wegovy” isn’t one decision — it’s several, depending on the trigger. Find your reason below, then take that specific next step to your provider.

Why you’re stopping	The honest reality	Smart next step to discuss with your provider
I hit my goal weight	This is the classic regain-risk moment in trials	Ask about a lower maintenance dose or a structured step-down — and build a habit plan before the last dose
Cost / insurance dropped me (the #1 real-world reason)	This is an access problem, not a failure — and lower-cost brand options exist now	Check insurance and current brand Wegovy prices before you create a gap (see the next section)
Side effects	Often dose-related; a lower dose may be tolerable	Ask about a dose reduction before quitting; know the red-flag symptoms
Supply / access changed	Disruptions push people off involuntarily	Re-establish a stable, legitimate source; ask about alternatives
Injection fatigue (“I dread the shot”)	Real and common	Ask about the Wegovy pill or another option — you may not have to quit
Planning a pregnancy	This is a medical reason to stop	The label says stop at least 2 months before trying to conceive — plan timing with your provider
Upcoming surgery	Anesthesia teams have specific concerns	Tell your surgeon and anesthesia team you’re on a GLP-1; follow their instructions
I just want off	A valid choice	Build a real off-ramp plan instead of stopping cold

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What if cost or insurance is forcing you to stop Wegovy?

Answer: If cost or a coverage change is pushing you off Wegovy, treat it as an access problem first — not a stop-the-medicine decision. Before you create a long gap, check the exact reason coverage ended and what the brand actually costs now, because Wegovy pricing changed a lot in 2026. With eligible commercial insurance that covers it, the brand can cost as little as $25 a month; without insurance, official cash prices now start around $149 a month for some doses.

First, find out why coverage ended

Your prior authorization (your insurer’s pre-approval) expired.
Your employer dropped weight-loss drug coverage. For example, Blue Cross Blue Shield of Massachusetts ended coverage for GLP-1 medications except for type 2 diabetes, effective upon plan renewal starting January 1, 2026.
The plan now requires “step therapy” (trying a cheaper option first).
Required paperwork or weight documentation was missing.

Some of these can be appealed or renewed. It’s worth one phone call before you assume it’s retail-or-nothing.

What brand Wegovy actually costs now

Official Novo Nordisk (NovoCare Pharmacy) prices, verified the week of May 26, 2026. GLP-1 pricing changes fast, so we re-check it monthly.

Option	Cash price (self-pay)	Notes
Wegovy pill — 1.5 mg	$149/month	One bottle of 30 tablets
Wegovy pill — 4 mg	$149/month	Through Aug 31, 2026, then $199/month
Wegovy pill — 9 mg & 25 mg	$299/month	—
Wegovy pen — 0.25 & 0.5 mg	$199/month	Eligible new self-pay patients, up to 2 fills, through June 30, 2026
Wegovy pen — 0.25–2.4 mg	$349/month	After the intro offer
Wegovy HD pen — 7.2 mg	$399/month	Highest dose
With commercial insurance that covers Wegovy	As little as $25/month	Via the Wegovy Savings Offer; eligibility limits apply; government beneficiaries (Medicare/Medicaid) are excluded

Medicare and Medicaid: CMS says eligible Medicare Part D members can access certain GLP-1 drugs — including Wegovy — for a $50 monthly copay through the Medicare GLP-1 Bridge, running July 1, 2026 through December 31, 2027. For Medicaid, the BALANCE model may expand GLP-1 access in states that choose to take part. Either way, coverage depends on eligibility and prior authorization, so check your specific plan. See our Medicare GLP-1 Bridge guide.

A fast way to check coverage and price

If you’ve decided you want to keep taking brand-name Wegovy and the only barrier is cost or coverage, you can check both in a few minutes. Ro offers access to FDA-approved Wegovy — both the pen and the pill — and if you’re using insurance, Ro says its insurance team checks your coverage and submits the prior-authorization paperwork for you. Ro’s membership is $39 for the first month, then $149/month — or as low as $74/month if you prepay for a year. (The membership is separate from the cost of the medication.)

If that fits your situation, you can check whether your insurance covers Wegovy and see current pricing before you create a gap. Sesame (sponsored affiliate link, opens in a new tab) is another option that offers brand Wegovy and lets you choose your clinician.

Check insurance coverage and current Wegovy pricing →

Eligibility and final pricing are set by Ro and your insurance plan.

One thing we won’t do: tell you that compounded semaglutide is the same as Wegovy. It isn’t. Compounded semaglutide is mixed by a pharmacy and is not an FDA-approved finished medicine like Wegovy. It’s a different product with different oversight. If a clinician suggests it, that’s a separate conversation — not a like-for-like swap for the brand you were on.

What if side effects are why you want to stop?

Answer: Some Wegovy side effects ease on their own as the drug clears, and others may improve at a lower dose — so quitting isn’t always the only fix. But certain symptoms are red flags that need medical attention, not a do-it-yourself stop. Talk to your provider before stopping, especially if you take insulin or other diabetes medicines.

Symptom	Usually worth discussing soon	Call your provider or seek care promptly	Why it matters
Nausea, vomiting, diarrhea, constipation, reflux	✓ (often eases as the drug clears or at a lower dose)	If vomiting won’t stop or you can’t keep fluids down	Dehydration can affect your kidneys
Tiredness, or dreading the weekly shot	✓ (ask about the pill or a different option)	—	A form you’ll actually stick with works better
Severe stomach pain, especially spreading to your back	—	✓ Same day	Possible pancreas problem (pancreatitis)
Yellowing of skin or eyes, pain under the right ribs	—	✓ Same day	Possible gallbladder problem
Swelling, hives, trouble breathing	—	✓ Urgent	Possible allergic reaction
Repeated low blood sugar (if you use insulin/sulfonylurea)	—	✓ Promptly	Your diabetes meds may need adjusting

Wegovy’s label warns about serious but less common issues including pancreatitis, gallbladder disease, kidney problems linked to dehydration, and a thyroid tumor risk seen in animal studies (which is why it’s not for people with a personal or family history of medullary thyroid cancer or the condition MEN 2). If anything feels severe, don’t tough it out — get care.

Can you restart Wegovy after stopping?

Answer: Yes — stopping Wegovy isn’t a one-way door, and many people restart. But the safe way to restart depends on how long you’ve been off, your old dose, and why you stopped. After missing two or more weekly doses, the label says you may resume as scheduled or start the dose build-up again to reduce stomach side effects — a decision to make with your provider, not on your own.

Key point most people miss: you usually can’t jump straight back to your old high dose after a long break. Your tolerance to the side effects fades while you’re off the drug, so restarting at full strength can make you feel awful. Your provider will likely “re-titrate” you — meaning start low and step back up.

How long you’ve been off	What the label suggests
Missed one weekly dose	Take it within 2 days if your next dose is more than 2 days away; otherwise skip and resume on schedule
Missed 2+ weekly doses	Resume on schedule, or restart the step-up from a lower dose to ease side effects
A longer break	A provider-guided restart, usually re-titrating from a lower dose

When you talk to your provider about restarting, bring these details: the date and amount of your last dose, your current and lowest weight, why you stopped, any side effects you had, your diabetes medicines, and whether pregnancy or surgery is in the picture. Restarting after regaining some weight is common and normal. It is not a sign you did anything wrong.

Is switching to the Wegovy pill or another option better than stopping?

Answer: If Wegovy still makes medical sense but the shot, the cost, or access is the real problem, switching may beat stopping. Wegovy’s label gives exact steps for moving between the 2.4 mg injection and the 25 mg pill, and there are now other FDA-approved options to discuss. The label also says not to combine Wegovy with other semaglutide products or other GLP-1 medicines.

Switching between the Wegovy shot and the Wegovy pill

Shot to pill: one week after your last 2.4 mg injection, you can start the 25 mg Wegovy tablet once daily.
Pill to shot: the day after your last tablet, you can start the 2.4 mg weekly injection.
If you can’t tolerate the 25 mg pill, your provider may switch you to the 1.7 mg injection.

This is a real option for injection fatigue — you may be able to keep the same medicine in a form you’ll actually stick with.

Your options at a glance

Option	What it is	A key detail	Best fit
Wegovy injection	Weekly semaglutide shot	Maintenance dose is 1.7 mg or 2.4 mg	You tolerate injections and want the most-studied form
Wegovy pill	Daily semaglutide tablet	Must be taken on an empty stomach with a short fast after	You want the same medicine without a needle
Foundayo (orforglipron)	Daily oral GLP-1 pill	Can be taken any time, with or without food	You want a flexible daily pill — discuss with your clinician
Any two GLP-1s together	—	The label says don’t stack GLP-1 medicines	Not an option — never combine them

A note on Foundayo (orforglipron): the FDA approved it in 2026 for adults with obesity, or overweight with a weight-related condition, used with a reduced-calorie diet and more activity. Its main practical difference from the Wegovy pill is convenience — you can take Foundayo any time of day with or without food, while the Wegovy tablet has to be taken on an empty stomach with a short fast. We mention it only as something to ask your clinician about — not a swap for Wegovy and not a recommendation.

How to keep the weight off: your step-by-step plan after Wegovy

Answer: There’s no guaranteed way to prevent all regain after stopping Wegovy, but a simple, planned approach gives you early warning and clear next steps instead of panic. The goal is to replace “stop and hope” with monitoring, support, and decisions you make ahead of time.

Before your last dose:

Write down your current weight and how your clothes fit.
Book a follow-up with your provider for a few weeks out.
Decide whether you’re truly stopping, switching, or just lowering your dose.
Agree with your provider on what would bring you back in for a check-in.

The first few weeks (while the drug still helps):

Make protein a priority at each meal — it helps you feel full.
Keep moving, and add some strength training if you can.
Protect your sleep. Poor sleep makes hunger worse.
Don’t crash-diet. Quick, extreme cuts tend to backfire.

As the drug fades (around weeks 5–7 and beyond):

Expect more hunger and “food noise.” It’s biology, not failure.
Watch how your clothes fit, not just the scale — both tell a story.
Pick a concrete check-in point with your provider before you stop — for example, if you notice a clear upward trend or your clothes start fitting differently, book a visit then, instead of waiting until you feel discouraged.

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What to ask your doctor before you stop Wegovy

Answer: The best appointment isn’t “should I stop?” It’s “given my reason for stopping, what’s the safest plan to protect my weight and my health markers?” Bring specific questions, because a focused conversation gets you a real plan instead of a shrug.

Print these and take them in:

Based on my dose and how long I’ve been on Wegovy, should I stop, lower my dose, switch, or stay on?
If I stop, what kind of regain should bring me back to see you?
Should we recheck my blood pressure, blood sugar (A1c), cholesterol, or waist size?
If I miss several doses, what dose should I restart at?
If side effects are the issue, would a lower dose or slower build-up help?
If cost is the issue, can we appeal my coverage or use a manufacturer savings program?
If I’m planning a pregnancy, when exactly should I stop?
If I’m having surgery, what should my anesthesia team know?

What about pregnancy or surgery?

Answer: Both pregnancy and surgery are medical reasons that may require stopping Wegovy, and both have specific timing. Wegovy’s FDA label says to stop at least 2 months before a planned pregnancy because the drug stays in your body a long time. For surgery, tell your care team you’re on a GLP-1 so they can plan around it.

If you’re trying to conceive, this isn’t a “decide later” item — the 2-month window is on the FDA label because of semaglutide’s long half-life, and the label advises stopping as soon as you know you’re pregnant. Plan the timing with your provider.

For surgery or any procedure with anesthesia, GLP-1 medicines can slow stomach emptying, which matters for sedation. Tell your surgeon and anesthesia team well ahead of time and follow their instructions on when to pause.

What we verified

We built this page from primary sources, not other blogs. Here’s exactly what we checked and when. GLP-1 pricing and coverage change quickly, so we re-verify the money items monthly. Last verified: May 30, 2026. Next pricing check: June 30, 2026.

Claim	Source type	Last verified
Semaglutide half-life ~1 week; present ~5-7 weeks after the last dose	FDA label (DailyMed)	May 30, 2026
STEP 1 extension: ~two-thirds of lost weight regained within 1 year after stopping	Peer-reviewed trial (Diabetes, Obesity and Metabolism, 2022)	May 30, 2026
Continued semaglutide outperformed switching to placebo (STEP 4)	Peer-reviewed trial (JAMA, 2021)	May 30, 2026
Stopping newer drugs: ~0.8 kg/month regain; health markers drift back over ~1.5 years	Systematic review (The BMJ, Oxford, 2026)	May 30, 2026
Real-world: 8.4% lost, ~0.5% of body weight regained, ~45% kept losing/stayed the same	Real-world study (Diabetes, Obesity and Metabolism, Cleveland Clinic, 2026)	May 30, 2026
Missed-dose rules; shot-to-pill switching; 1.7 mg/2.4 mg maintenance; stop >=2 months before pregnancy	FDA label (DailyMed)	May 30, 2026
Wegovy cash and insured pricing	NovoCare / Wegovy.com (official)	May 30, 2026
Medicare GLP-1 Bridge: $50/month copay, July 1, 2026-Dec 31, 2027	CMS (official)	May 30, 2026
Ro offers Wegovy pen + pill; membership $39 first month, then $149/mo or as low as $74/mo annual	Ro (official)	May 30, 2026
Foundayo (orforglipron) FDA-approved 2026; taken with or without food	FDA / Eli Lilly (official)	May 30, 2026

Frequently asked questions

About weight regain after stopping Wegovy.

Will I gain all the weight back if I stop Wegovy?

Not necessarily. In the STEP 1 extension trial, people regained about two-thirds of their lost weight within a year of stopping cold. But in a 2026 Cleveland Clinic real-world study of nearly 8,000 adults, people treated for obesity regained only about 0.5% of their body weight on average, and about 45% kept losing or stayed the same -- usually by tapering, switching, or restarting. How much you regain depends heavily on whether you keep up some form of treatment or support.

How long does Wegovy stay in your system?

Semaglutide has a half-life of about one week, and it stays in your body for roughly 5 to 7 weeks after your last dose, according to Wegovy's FDA label. That's why appetite returns gradually rather than all at once.

How soon after stopping Wegovy will I start gaining weight?

It's gradual, not overnight. Because the drug fades over about 5 to 7 weeks, hunger usually returns first. The 2026 BMJ/Oxford review found that after stopping newer drugs like semaglutide, regain averaged about 0.8 kg (1.8 lb) per month, though individual timing varies.

Can you taper off Wegovy?

Wegovy's FDA label does not include a formal taper-off schedule. Some clinicians still lower the dose gradually or move a patient to a lower maintenance dose rather than stopping abruptly. There's no one right approach -- it should be decided with your provider based on your situation.

Can I stop Wegovy cold turkey?

The label doesn't include a formal taper schedule, but your stop or restart plan should still come from your provider -- especially if you have diabetes, heart disease, severe side effects, pregnancy plans, or upcoming surgery.

What if my insurance stopped covering Wegovy?

Treat it as an access problem first. Check the exact reason coverage ended (an expired prior authorization, an employer dropping weight-loss coverage, or a new step-therapy rule), then compare current brand prices and savings options before creating a gap. With eligible commercial insurance that covers it, Wegovy can cost as little as $25/month; cash prices now start around $149/month for some doses.

Do you have to take Wegovy forever?

Not everyone does, but Wegovy is meant for long-term weight management, not a short course. Whether you stay on it depends on your health, results, side effects, cost, and your provider's guidance. Many people stay on a lower maintenance dose rather than stopping entirely.

Is Wegovy withdrawal real?

The label does not describe a dependence-style withdrawal. What people usually mean by withdrawal is the return of appetite, cravings, and food noise as the drug leaves the body.

Can I switch from the Wegovy shot to the Wegovy pill?

Yes. The label says you can start the 25 mg Wegovy tablet one week after your last 2.4 mg injection, and switch back to the injection the day after your last tablet. If you can't tolerate the 25 mg tablet, your provider may move you to the 1.7 mg injection. Don't make the switch without your provider.

What's the difference between the Wegovy pill and Foundayo?

Both are once-daily oral GLP-1 pills, but the Wegovy pill (semaglutide) must be taken on an empty stomach with a short fast afterward, while Foundayo (orforglipron) can be taken any time of day, with or without food. They are different medicines -- which one fits you is a decision for your clinician.

What dose do you restart Wegovy at after a break?

It depends on how long you've been off. After two or more missed weekly doses, the label says you may resume on schedule or restart the step-up from a lower dose to ease side effects. After a longer break, providers usually re-titrate you from a lower dose, because tolerance fades while you're off it.

Is compounded semaglutide the same as Wegovy?

No. Wegovy is an FDA-approved brand-name medicine. Compounded semaglutide is mixed by a pharmacy and is not an FDA-approved finished drug. They are not interchangeable, and compounded versions shouldn't be treated as a direct swap for the brand.

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